解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::T helper type (Th17) cytokines such as interleukin (IL)-17A and IL-22 are important in maintaining mucosal barrier function and may be important in the pathogenesis of inflammatory bowel diseases (IBDs). Here, we analyzed cells from the colon of IBD patients and show that Crohn's disease (CD) patients had significantl...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2013.31
更新日期:2014-01-01 00:00:00
abstract::Bacterial-induced intestinal inflammation is crucially dependent on interleukin (IL)-23 and is associated with CD4(+) T helper type 1 (Th1) and Th17 responses. However, the relative contributions of these subsets during the induction and resolution of colitis in T-cell-sufficient hosts remain unknown. We report that H...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2013.11
更新日期:2013-11-01 00:00:00
abstract::Celiac disease (CD) is a chronic small intestinal inflammation precipitated by gluten ingestion. According to case reports, interferon (IFN)-α administration may induce development of overt CD. Plasmacytoid dendritic cells (PDCs) were thought to be the source of IFN-α and promote a T helper type 1 response leading to ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.136
更新日期:2013-09-01 00:00:00
abstract::De novo differentiation of CD4(+)Foxp3(+) regulatory T cells (induced (i) Tregs) occurs preferentially in the gut-associated lymphoid tissues (GALT). We addressed the contribution of background genetic factors in affecting the balance of iTreg, T helper type 1 (Th1), and Th17 cell differentiation in GALT in vivo follo...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.102
更新日期:2013-05-01 00:00:00
abstract::As the Bacillus Calmette-Guérin (BCG) vaccine does not confer long-lasting protection against lung Mycobacterium tuberculosis infection, the development of more efficient vaccines is greatly needed. Here, we used mycobacterial low-molecular weight proteins of the 6-kDa Early Secreted Antigenic Target (ESAT-6) protein ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.92
更新日期:2013-05-01 00:00:00
abstract::Mucus, with its burden of inspired particulates and pathogens, is cleared from mucosal surfaces of the airways by cilia beating within the periciliary layer (PCL). The PCL is held to be "watery" and free of mucus by thixotropic-like forces arising from beating cilia. With radii of gyration ~250 nm, however, polymeric ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.81
更新日期:2013-03-01 00:00:00
abstract::Colonization of the nasopharyngeal mucosa by meningococcus and other polysaccharide (PS)-encapsulated bacteria precedes invasion. PS-conjugate vaccines induce PS-specific B-cell memory (B(MEM)) and also prevent colonization, thus blocking person-to-person transmission, generating herd protection. However, in isolation...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.70
更新日期:2013-03-01 00:00:00
abstract::Human papillomaviruses (HPV)-related cervical cancer is the second leading cause of cancer death in women worldwide. Despite active development, HPV E6/E7 oncogene-specific therapeutic vaccines have had limited clinical efficacy to date. Here, we report that intravaginal (IVAG) instillation of CpG-ODN (TLR9 agonist) o...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.83
更新日期:2013-03-01 00:00:00
abstract::Chlamydia trachomatis (Ct) is an obligate intracellular bacterial pathogen. Previously, we showed that infection of human trophoblast cells by Ct triggers the secretion of the pro-inflammatory cytokine, interleukin (IL)-1β. The aim of this study was to understand the innate immune pathways involved in trophoblast prod...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.63
更新日期:2013-03-01 00:00:00
abstract::Whereas gut IgA responses to the microbiota may be multi-centered and diverse, little is known about IgA responses to T-cell-dependent antigens following oral immunizations. Using a novel approach, gut IgA responses to oral hapten (4-hydroxy-3-nitrophenyl)acetyl-cholera toxin (NP-CT) conjugates were followed at the ce...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.56
更新日期:2013-01-01 00:00:00
abstract::Intestinal dendritic cells (DCs) continuously migrate through lymphatics to mesenteric lymph nodes where they initiate immunity or tolerance. Recent research has focused on populations of intestinal DCs expressing CD103. Here we demonstrate, for the first time, the presence of two distinct CD103(-) DC subsets in intes...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.53
更新日期:2013-01-01 00:00:00
abstract::Helminth infection leads to the local proliferation and accumulation of macrophages in tissues. However, the function of macrophages during helminth infection remains unclear. SH2-containing inositol 5'-phosphatase 1 (Ship1, Inpp5d) is a lipid phosphatase that has been shown to play a critical role in macrophage funct...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.29
更新日期:2012-09-01 00:00:00
abstract::Individuals with one atopic disease are far more likely to develop a second. Approximately half of all atopic dermatitis (AD) patients subsequently develop asthma, particularly those with severe AD. This association, suggesting a role for AD as an entry point for subsequent allergic disease, is a phenomenon known as t...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.14
更新日期:2012-05-01 00:00:00
abstract::T helper (Th)1 and Th2 cells play decisive roles in the regulation of resistance vs. susceptibility to pulmonary cryptococcosis. To study the function of interleukin (IL)-4 receptor (IL-4R) on Th cells in pulmonary cryptococcosis, we infected mice specifically lacking IL-4Rα on CD4(+) T cells (Lck(Cre)IL-4Rα(-/lox) mi...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2012.9
更新日期:2012-05-01 00:00:00
abstract::Epidemiological data indicate a link between rheumatoid arthritis (RA) and periodontal disease (PD). In vitro and in vivo studies have sought to dissect potential mechanisms by which PD may contribute to initiation and progression of RA. However, these are both multifactorial, chronic diseases, and their complex etiol...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2011.66
更新日期:2012-03-01 00:00:00
abstract::Proper colonic injury response requires myeloid-derived cells and Toll-like receptor/Myd88 signaling. However, the precise role of Myd88 signaling specifically in myeloid-derived cells that occurs during tissue damage is unclear. Therefore, we created a mouse line with Myd88 expression restricted to myeloid lineages (...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2011.65
更新日期:2012-03-01 00:00:00
abstract::The interleukin-23 (IL-23) pathway has emerged as a promising therapeutic target for inflammatory bowel disease. Although the pathogenic role of IL-23 receptor (IL-23R) on T lymphocytes is well established, its function on innate immune cells has not been thoroughly examined. Here we investigate the consequence of IL-...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2011.54
更新日期:2012-01-01 00:00:00
abstract::Levels of reactive free radicals are elevated in the airway during asthmatic exacerbations, but their roles in the pathophysiology of asthma remain unclear. We have identified subsets of myeloid-derived suppressor-like cells as key sources of nitric oxide and superoxide in the lungs of mice with evolving experimental ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2011.16
更新日期:2011-09-01 00:00:00
abstract::Peroxisome proliferator-activated receptor-γ (PPAR-γ) is widely expressed in macrophages and has been identified as a putative target for the development of novel therapies against inflammatory bowel disease (IBD). Computational simulations identified macrophages as key targets for therapeutic interventions against IB...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2010.75
更新日期:2011-05-01 00:00:00
abstract::Nedd4 family interacting protein 1 (Ndfip1) is an adaptor protein that regulates Itch, an E3 ubiquitin ligase that ubiquitylates JunB, thereby preventing interleukin (IL)-4 and IL-5 production. Mice lacking Ndfip1 or Itch develop T helper type 2 (T(H)2)-mediated inflammation in the skin and lungs and die prematurely. ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2010.69
更新日期:2011-05-01 00:00:00
abstract::Leptin is an adipocytokine that links nutrition to immunity. Previous observation that a genetic polymorphism in the leptin receptor affected susceptibility to Entamoeba histolytica infection led to the hypothesis that leptin signaling has a protective role during intestinal amebic infection. In this study we show tha...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2010.76
更新日期:2011-05-01 00:00:00
abstract::The study of animal immune physiology and animal models of human disease have accelerated many aspects of translational research by allowing direct, definitive investigations. In particular, the use of mice has allowed genetic manipulation, adoptive transfer, immunization, and focused cell and tissue sampling, which w...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2010.85
更新日期:2011-03-01 00:00:00
abstract::Intestinal CD8αα intraepithelial T lymphocytes (T-IELs) have a key role in mucosal immunity and, unlike other T cells, were proposed to differentiate locally. In apparent contradiction, these cells were also shown to originate from a wave of thymus migrants colonizing the gut in the first 3 weeks after birth. We here ...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2010.47
更新日期:2011-01-01 00:00:00
abstract::The ultimate goal for vaccination is to stimulate protective immunological memory. Protection against infectious diseases not only relies on the magnitude of the humoral immune response, but more importantly on the quality and longevity of it. Adjuvants are critical components of most non-living vaccines. Although lit...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2010.54
更新日期:2010-11-01 00:00:00
abstract::Oral tolerance refers to the observation that prior feeding of an antigen induces local and systemic immune tolerance to that antigen. Physiologically, this process is probably of central importance for preventing inflammatory responses to the numerous dietary and microbial antigens present in the gut. Defective oral ...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2010.25
更新日期:2010-07-01 00:00:00
abstract::Molecular mechanisms regulating transforming growth factor-beta (TGF-beta) induction of Foxp3 (forkhead box P3) expression and thus induction of induced regulatory T cells (Tregs) have been the focus of a great deal of study in recent years. It has become clear that this process is influenced by a number of factors as...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2010.7
更新日期:2010-05-01 00:00:00
abstract::Allergic diseases, which have reached epidemic proportions, are caused by inappropriate immune responses to a relatively small number of environmental proteins. The molecular basis for the propensity of specific proteins to promote maladaptive, allergic responses has been difficult to define. Recent data suggest that ...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2009.138
更新日期:2010-03-01 00:00:00
abstract::Induction of mucosal immunity is critical for protection from enteric pathogens. Heat shock protein gp96 is one of the primary peptide and protein chaperones located in the endoplasmic reticulum. We reported previously that a cell-secreted gp96-Ig fusion protein (gp96-Ig) mediated strong systemic, antigen-specific CD8...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2009.127
更新日期:2010-03-01 00:00:00
abstract::The gut mucosa is an important site of HIV immunopathogenesis with severe depletion of CD4+ T cells occurring during acute infection. The effect of prolonged anti-retroviral therapy (ART) on cycling and restoration of T lymphocytes in the gut remains unclear. Colon and terminal ileal biopsies and peripheral blood samp...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2009.129
更新日期:2010-03-01 00:00:00
abstract::The development of the primitive gut in the multicellular aquatic eukaryote was driven by the insufficient absorption of nutrients from the oceanic soup. The anatomy of this evolving specialized system invited its colonization by environmental prokaryotes and resulted in the establishment of the intestinal microflora....
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2009.123
更新日期:2010-01-01 00:00:00
abstract::Vaccine-mediated prevention of primary infection with human immunodeficiency virus (HIV) may require the sustained production of antibody at mucosal portals of entry. Here, we describe a novel approach of repeated mucosal immunization by delivering an HIV-1 envelope glycoprotein (gp) in a gel formulated for intravagin...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2009.110
更新日期:2010-01-01 00:00:00
abstract::Human immunodeficiency virus/simian immunodeficiency virus (HIV/SIV) infections are believed to infect minimally activated CD4(+) T cells after viral entry. Not much is known about why SIV selectively targets these cells. Here we show that CD4(+) T cells that express high levels of the alpha4beta7 heterodimer are pref...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2009.90
更新日期:2009-09-01 00:00:00
abstract::AIDS is mainly a sexually transmitted disease, and accordingly, mucosal tissues are the primary sites of natural human immunodeficiency virus type-1 (HIV-1) transmission. Mucosal immunoglobulin A (IgA) antibody specific for HIV-1 envelope gp41 subunit is one correlate of protection in individuals who are highly sexual...
journal_title:Mucosal immunology
pub_type: 杂志文章
doi:10.1038/mi.2009.89
更新日期:2009-09-01 00:00:00
abstract::HIV prevention mandates an understanding of the mechanisms of mucosal immunity with attention to some unique features of the epidemic and mucosal environment in the developing world. An effective vaccine will have to induce mucosal protection against a highly diverse virus, which is equipped with a number of immune ev...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2009.23
更新日期:2009-07-01 00:00:00
abstract::The mucosal immune system is charged with defending the host's vast interfaces with the outside world from the enormous and diverse group of microbes that colonizes these surfaces. A key means by which the mucosal immune system protects the host from such diverse microbes is using germ-line-encoded receptors that targ...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2009.9
更新日期:2009-05-01 00:00:00
abstract::Celiac disease is a multifactorial disorder and provides a privileged model to decipher how the interplay between environmental and genetic factors can alter mucosal tolerance to a food antigen, lead to chronic intestinal inflammation, and ultimately promote T-cell lymphomagenesis. Here we summarize how HLA-DQ2/8 mole...
journal_title:Mucosal immunology
pub_type: 评论,杂志文章,评审
doi:10.1038/mi.2008.75
更新日期:2009-01-01 00:00:00
abstract::Nucleotide oligomerization domain (NOD)2 is a member of the NOD-like receptor family of proteins that initiate inflammatory responses when exposed to ligands derived from bacterial components that gain access to the intracellular milieu. It is thus somewhat paradoxical that polymorphisms in the gene that encode NOD2 (...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2008.42
更新日期:2008-11-01 00:00:00
abstract::Our studies have focused on understanding the mechanisms of interactions between the indigenous intestinal flora and the mammalian host in both physiological and nonphysiological conditions. In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of ...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2008.49
更新日期:2008-11-01 00:00:00
abstract::Cells of the mononuclear phagocyte system (MPS) are found in large numbers in every organ of the body, where they contribute to innate and acquired immunity and homeostasis. This review considers the locations of MPS cells, surface markers that distinguish subsets of monocytes and macrophages, the pathways of MPS diff...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2008.36
更新日期:2008-11-01 00:00:00
abstract::The tight connection between intestinal inflammation and arthritis in spondyloarthritis (SpA) has been studied extensively. Subclinical gut inflammation, which can be considered as a model for early Crohn's disease, was shown to be strongly associated with joint inflammation. Several early mucosal abnormalities were u...
journal_title:Mucosal immunology
pub_type: 杂志文章,评审
doi:10.1038/mi.2008.24
更新日期:2008-09-01 00:00:00